denoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome - Are Adenoviral Genes Expressed in Vector-based Vaccines?

This brief review was presented here to facilitate an independent and more balanced discussion on the potential risks due to the presence of adenovirus vector DNA (AstraZeneca, Johnson & Johnson, Sputnik V and others) or SARS-CoV-2 RNA (BioNTech/Pfizer, Moderna) in vaccines that are supposed to protect against Covid-19. Of course, injections of vector-based vaccines into human deltoid muscle is a different matter than rare chance events leading to recombination events between foreign and human DNAs in experimental systems as described above. Moreover, neither type nor frequency of consequences of rare vector integration events can be realistically assessed at present. The recently published results on the benefits of protection against Covid-19 offered by the BioNTech/Pfizer vaccines are encouraging Dagan et al. 2021]. Granted, the jury is still out on whether any of the vaccines’ will protect against the more dangerous new SARS-CoV-2 variants from the UK, South Africa, Brazil and unknown variants that might arise in the future given the poorly controlled levels of viral replication around the world. Lastly, we are ignorant about vaccine protection against the development of prolonged and late-onset symptoms of Covid-19.

https://www.sciencedirect.com/science/article/pii/S0168170221001738