Based on Extinct December 2021 Version of Ba.1
A 50 µg booster dose of mRNA-1273.214 met all pre-specified endpoints including superior neutralizing antibody response (geometric mean ratio)against the Omicron variant one month after administration when compared to the original mRNA-1273 vaccine.The booster dose of mRNA-1273.214 was generally well-tolerated, with side effects comparable to a booster dose of mRNA-1273 at the 50 µg dose level.
Great, I thought at first, perhaps I should give up on my vaccine skepticism, sign up to receive the new “Omicron vaccine”, tweet a picture with a Band-Aid on my arm, and be protected from Covid forever with the new “effective” version. Somehow, though, I decided to dig a little deeper, did my own research, and decided to remain a Covid vaccine skeptic.
Omicron Vaccine? Which Omicron?
Moderna repeatedly talks about “response against the Omicron variant”. However, there is not one “Omicron Variant”. Numerous “Omicron Variants” appeared since Dec 2021: Ba1.1, Ba.2, Ba.2.12.*, Omicron XE, Ba.3, Ba.4, and Ba.5, just to name a few.
Moderna is committing a sleight of hand, calling its new formulation an “Omicron vaccine”.
Moderna “Rebrands” Trial Midstream
Obviously, Moderna’s leaders are very bright and when they saw Ba.1 variant die off, they immediately thought along the same lines I did and decided to rebrand their trial and remove overt references to B.1.1.529 from the name of the trial.
No doubt, this change was introduced to encourage second booster uptake among the dwindling vaccine enthusiasts, who would be better persuaded by “Omicron vaccine” as opposed to “B.1.1.529 vaccine”.
Strange Pivot to “Bivalent” Vaccine Using Wuhan Variant
Why, may I ask, add a two-years-ago extinct Wuhan variant? I would like others to weigh in, but my own explanation is that the pure Ba.1 vaccine did not work well at all due to Original Antigenic Sin, so they had to make a change on April 11.
In other words, due to vaccinated people’s antigenic fixation on the Wuhan variant, the vaccine needs to contain Wuhan variant spikes to elicit any immune response at all. And that is why Wuhan spikes were added. Due to an extreme lack of data, the above is speculation, that I would like to see confirmed or disconfirmed.
Antibody Titers: Garbage in, Garbage Out
Moderna’s release contains gleaming references to “antibody titers”.
mRNA-1273.214 met all primary endpoints in the Phase 2/3 trial including neutralizing antibody response against Omicron when compared to a 50 µg booster dose of mRNA-1273in baseline seronegative participants . Pre-specified criteria for superiority as measured by neutralizing geometric mean titer ratio (GMR) with the lower bound of the confidence interval >1 was met. The GMR and corresponding 97.5% confidence interval was 1.75 (1.49, 2.04). A booster dose of mRNA-1273.214 increased neutralizing geometric mean titers (GMT) against Omicron approximately 8-fold above baseline levels. Primary endpoints of non-inferiority against ancestral SARS-CoV-2 were also met, with GMR against ancestral SAR-COV-2 (D614G) of 1.22 (1.08-1.37).
I would like to remind everyone that these antibodies are only good for counting: numerous people catch Covid soon after second boosters, despite high antibody counts. Gavin Newsom is one example of thousands.
Incidentally, Moderna collects information about Covid infections among the trial participants, but will not have to disclose these outcomes for a year. Whether this “Omicron vaccine” prevents Omicron, is a secondary — less important — outcome, and will not need to be disclosed for a whole year.
Despite all that, this ridiculous variant vaccine will be soon approved by the corrupt FDA.
Ba.1 the worst Long Term Antigen Candidate
The continuous evolution of Omicron poses great challenges to SARS-CoV-2 herd immunity and suggests that BA.1-derived vaccine boosters may not be ideal for achieving broad-spectrum protection.
Variant Whack-a-Mole Game is Very Profitable
Remember how you were a kid and your parents bought you a whack-a-mole game? Now imagine you could get $22 for every whack, wouldn’t you want that? I bet you would be excited!
As a pro-business person, I am very happy for Moderna. I am less happy for people who will be reinjected and reinfected with the resulting cornucopia of variants, but oh well. Who cares? Nobody at the FDA.